Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

• Sambasivarao Kotha,
• Milind Meshram and
• Chandravathi Chakkapalli

Beilstein J. Org. Chem. 2018, 14, 2468–2481, doi:10.3762/bjoc.14.223

• the ring-closure product 25 (84%). Finally, CAN oxidation gave the desired tetracyclic compound 26 in 84% yield (Scheme 3). Spirocycles In another event, an efficient approach to spirocyclopentane derivatives has been described, where the combination of RCM and SM coupling was employed [34]. In this

Mechanistic studies on the CAN-mediated intramolecular cyclization of δ-aryl-β-dicarbonyl compounds

• Brian M. Casey,
• Dhandapani V. Sadasivam and
• Robert A. Flowers II

Beilstein J. Org. Chem. 2013, 9, 1472–1479, doi:10.3762/bjoc.9.167

• radical intermediates. Furthermore, DFT computational studies were used to rationalize the observed site selectivity in the 2-tetralone products. Keywords: CAN oxidation; β-dicarbonyls; free radical; radical arylations; tetralones; Introduction 2-Tetralones are important intermediates or components of

Single enantiomer synthesis of α-(trifluoromethyl)-β-lactam

• Václav Jurčík,
• Alexandra M. Z. Slawin and
• David O'Hagan

Beilstein J. Org. Chem. 2011, 7, 759–766, doi:10.3762/bjoc.7.86

• nitrate (CAN) oxidation offered a milder deprotection method [15]. The aza-Michael reaction proved straightforward to generate 4b and then cyclisation again using thionyl chloride and triethylamine gave β-lactams 5b in a 40% de, presumably again a thermodynamically biased isomer ratio. The

Diels- Alder reactions using 4,7-dioxygenated indanones as dienophiles for regioselective construction of oxygenated 2,3-dihydrobenz[f]indenone skeleton

• Natsuno Etomi,
• Takuya Kumamoto,
• Waka Nakanishi and
• Tsutomu Ishikawa

Beilstein J. Org. Chem. 2008, 4, No. 15, doi:10.3762/bjoc.4.15

• ). Intramolecular Friedel-Crafts reaction of 2,5-dimethoxybenzenepropanoic acid (15) and the 4-brominated derivative 16 [31], by a procedure modified from the synthesis of 4 [23], afforded the corresponding indanones 17 and 18. Cerium ammonium nitrate (CAN) oxidation [32] of indanone 17 smoothly afforded